Clinical-Stage Biopharmaceutical · Australia · Global

Redefining treatment
for inflammatory
& autoimmune disease.

Akaal Pharma is advancing a first-in-class S1P1 receptor programme — with breakthrough clinical results in both topical and oral formulations, and a superior safety profile over existing therapies.

View Pipeline Partner With Us
139
Phase 2 patients
Topical · Completed
40
Phase 1 volunteers
Oral · Completed
2
Active programmes
Topical & Oral
S1P1
Clinically validated
therapeutic target
S1P1

Transforming the
treatment landscape.

Akaal Pharma develops novel therapies that prioritise patient safety, efficacy, and affordability — targeting inflammatory and autoimmune diseases through a highly druggable biological receptor with validated clinical potential.

We undertake early-stage drug discovery, creating best-in-class and first-in-class drug candidates for areas of significant unmet medical need.

First-in-Class
Novel S1P1 modulators with breakthrough profiles not seen in existing drug classes.
Superior Safety
No immune suppression, bradycardia, or significant adverse effects — a profile that sets us apart.
Dual Programme
Both topical and oral development programmes advancing simultaneously across multiple indications.
Patient Focus
Every programme designed with affordability and accessibility at its core.

Two breakthrough
programmes. One target.

Both Takp-119 (topical) and Oakp-11 (oral) have completed significant clinical milestones, with compelling safety and efficacy data positioning Akaal Pharma as a leader in S1P1-targeted therapeutics.

Programme
Discovery
Preclinical
Phase 1
Phase 2
Phase 3
Approval
Takp-119
Atopic Dermatitis / Pruritus
Phase 2 Complete
Oakp-11
Autoimmune Diseases
Phase 1 Complete
Oakp-11
Neuropathic Pain
Exploratory
Topical Programme
Takp-119
S1P1 Agonist · First-in-Class Dermatological
Phase 2 completed in 139 patients with atopic dermatitis and pruritus
Significant efficacy with no immune suppression, skin irritation, thinning or discolouration
Non-steroidal alternative with favourable safety profile for mild to moderate AD
Targeting a broad range of inflammatory skin conditions beyond atopic dermatitis
✓ Phase 2 complete · Advancing to Phase 3
Oral Programme
Oakp-11
S1P1 Modulator · Best-in-Class Systemic
Phase 1 completed in 40 healthy volunteers with dose-dependent drug exposure
No significant immune suppression, bradycardia, or other adverse effects
First S1P1 drug combining: high selectivity, strong activity, minimal lymphopenia, cardiovascular safety and favourable PK profile
Exploratory potential in neuropathic pain as first-in-class candidate
✓ Phase 1 complete · Advancing to Phase 2

A clinically validated
target. A superior
approach.

The S1P1 (sphingosine-1-phosphate receptor 1) is a highly druggable biological receptor with broad relevance across multiple disease areas. Existing S1P1 therapies carry significant limitations — Akaal Pharma's approach overcomes them all.

01
Clinically validated mechanism — S1P1 modulation is implicated in multiple physiological processes with proven therapeutic relevance across autoimmune and inflammatory conditions.
02
Overcomes existing limitations — current S1P1 agonists carry immune suppression, cardiac, and tolerability issues. Our candidates demonstrate none of these.
03
High receptor selectivity — precise targeting reduces off-target effects and enables a cleaner, safer pharmacological profile.
04
Multiple indications — the S1P1 mechanism unlocks opportunities across dermatology, autoimmunity, and neuropathic pain from a single platform.
S1P1
Sphingosine-1-Phosphate Receptor 1
Atopic Dermatitis Pruritus Autoimmune Disease Multiple Sclerosis Neuropathic Pain Inflammatory Skin Rheumatoid Arthritis Inflammatory Bowel
Partnering

Seeking partners who
want to make a difference.

01
Licensing

We are open to licensing discussions for Takp-119 and Oakp-11 — particularly with partners who have established commercial infrastructure in dermatology and autoimmune markets globally.

02
Co-Development

We welcome co-development partnerships with pharmaceutical companies and research institutions to accelerate clinical programmes and expand into new indications and geographies.

03
Investment

We are seeking strategic investors to support Phase 3 development of Takp-119 and Phase 2 advancement of Oakp-11 — a compelling risk-return profile backed by strong clinical data.

Ready to advance the next generation of S1P1 therapeutics?

Whether you are a pharmaceutical partner, research organisation, or strategic investor — we would welcome the opportunity to explore how we can work together.

Get in Touch info@akaalpharma.com

Let's start a
conversation.

Email
CEO
Headquarters
Akaal Pharma Pty Ltd
Australia